Issue 50, 2021
From the journal:

Chemical Communications

Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter†

Joshua J. Woods, ORCID logo ab   Madison X. Rodriguez,c   Chen-Wei Tsai,c   Ming-Feng Tsai ORCID logo c  and  Justin J. Wilson ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA
E-mail: jjw275@cornell.edu

b Robert F. Smith School for Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA

c Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Abstract

We report our investigation into the MCU-inhibitory activity of Co3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore.

Graphical abstract: Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

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Article information

DOI
https://doi.org/10.1039/D1CC01623G
Article type
Communication
Submitted
25 Mar 2021
Accepted
24 May 2021
First published
27 May 2021

Chem. Commun., 2021,57, 6161-6164

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Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

J. J. Woods, M. X. Rodriguez, C. Tsai, M. Tsai and J. J. Wilson, Chem. Commun., 2021, 57, 6161 DOI: 10.1039/D1CC01623G

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