Issue 46, 2021
From the journal:

Chemical Communications

The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4†

Xingguang Cai,a   Sacha Javor,a   Bee Ha Gan,a   Thilo Köhlerb  and  Jean-Louis Reymond ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland
E-mail: jean-louis.reymond@dcb.unibe.ch

b Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland

Abstract

pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.

Graphical abstract: The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

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Article information

DOI
https://doi.org/10.1039/D1CC01838H
Article type
Communication
Submitted
06 Apr 2021
Accepted
04 May 2021
First published
05 May 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 5654-5657

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The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

X. Cai, S. Javor, B. H. Gan, T. Köhler and J. Reymond, Chem. Commun., 2021, 57, 5654 DOI: 10.1039/D1CC01838H

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