Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy

Lingshan Liu; Xiang Zhou; Rongrong Zheng; Jiaqi Huang; Renjiang Kong; Yanmei Li; Chang Wang; Ali Chen; Shiying Li; Hong Cheng

doi:10.1039/D1CC02318G

Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy†

Lingshan Liu,‡^a Xiang Zhou,‡^a Rongrong Zheng,‡^b Jiaqi Huang,^a Renjiang Kong,^a Yanmei Li,^a Chang Wang,^b Ali Chen,*^b Shiying Li

*^b and Hong Cheng

*^a

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* Corresponding authors

^a School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, P. R. China
E-mail: chengh@smu.edu.cn

^b School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China
E-mail: lisy-sci@gzhmu.edu.cn, chenali2004@163.com

Abstract

A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system for enhanced PDT, which provides synergistic effects for tumor precision therapy in consideration of the unfavorable tumor microenvironments.

Chemical Communications

Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy†

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