Issue 64, 2021
From the journal:

Chemical Communications

A metal–organic cage-based nanoagent for enhanced photodynamic antitumor therapy†

Wen-Yan Li,‡a   Chao-Wei Zhao,‡b   Yue-Feng Zhang,b   Qun Guan, ORCID logo a   Jing-Jing Wan,a   Jian-Ping Ma, ORCID logo a   Yan-An Li ORCID logo *a  and  Yu-Bin Dong ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China
E-mail: yananli@sdnu.edu.cn, yubindong@sdnu.edu.cn

b Institute of Applied Chemistry, Jiangxi Academy of Sciences, Nanchang 330096, P. R. China

Abstract

Herein, we report, for the first time, a Pd6L8(NO3)5.4(ICG)6.6 (ICG = indocyanine green) cage-based hexagonal nanoplate (3) via a combined nanoprecipitation and solid-state anion-exchange approach. Nanoplate 3 possesses enhanced near-infrared (NIR) light-triggered 1O2 generation, high cellular uptake selective lysosome-targeting ability, and, consequently, excellent antineoplastic activity.

Graphical abstract: A metal–organic cage-based nanoagent for enhanced photodynamic antitumor therapy

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Article information

DOI
https://doi.org/10.1039/D1CC02629A
Article type
Communication
Submitted
19 May 2021
Accepted
09 Jul 2021
First published
09 Jul 2021

Chem. Commun., 2021,57, 7954-7957

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A metal–organic cage-based nanoagent for enhanced photodynamic antitumor therapy

W. Li, C. Zhao, Y. Zhang, Q. Guan, J. Wan, J. Ma, Y. Li and Y. Dong, Chem. Commun., 2021, 57, 7954 DOI: 10.1039/D1CC02629A

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