Issue 53, 2021

Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants

Abstract

Engineering of a promiscuous lactonase via semi-rational evolution gave a 1007-fold improvement in its catalytic activity in the degradation of triphenyl phosphate (TPHP). TPHP is a typical bulky organophosphate flame retardant (OPFR) and is widely used in industry. To the best of our knowledge, this is the first artificial enzyme capable of degrading OPFRs.

Graphical abstract: Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants

Supplementary files

Article information

Article type
Communication
Submitted
20 May 2021
Accepted
03 Jun 2021
First published
04 Jun 2021

Chem. Commun., 2021,57, 6475-6478

Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants

Y. Zhang, X. Zhang, H. Cheng, M. R. H. Nina, J. Ge and Y. Bai, Chem. Commun., 2021, 57, 6475 DOI: 10.1039/D1CC02657G

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