Unexpectedly rigid short peptide foldamers in which NH–π and CH–π interactions are preserved in solution

Abstract

NH–π and CH–π interactions, due to their weak character, are not easily identified in solution. We report a group of isolable short peptides with stable folds, in which NH–π and CH–π main chain–side chain interactions can be detected in solution by means of NMR and ATR-IR spectroscopy.