Pd-catalyzed C(sp3)–C(sp) bond formation in iodocyclobutenes

Carlos Lázaro-Milla; M. Teresa Quirós; Diego J. Cárdenas; Pedro Almendros

doi:10.1039/D1CC03087F

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Pd-catalyzed C(sp³)–C(sp) bond formation in iodocyclobutenes†

Carlos Lázaro-Milla,

^a M. Teresa Quirós,

^bc Diego J. Cárdenas

*^b and Pedro Almendros

*^d

Author affiliations

* Corresponding authors

^a Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, Madrid 28040, Spain

^b Departamento de Química Orgánica, Facultad de Ciencias, Institute for Advanced Research in Chemical Sciences, IadChem, Universidad Autónoma de Madrid, Av. Francisco Tomás y Valiente 7, Cantoblanco, Madrid 28049, Spain
E-mail: diego.cardenas@uam.es

^c Departamento de Química Orgánica y Química Inorgánica, Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, Madrid 28805, Spain

^d Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, Madrid 28006, Spain
E-mail: palmendros@iqog.csic.es

Abstract

A synthesis of skipped 1,4-enynes through functionalization of the cyclobutene core with alkynes has been achieved, suggesting an unusual pathway of oxidative addition in tertiary iodoalkanes.

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Article information

DOI: https://doi.org/10.1039/D1CC03087F
Article type: Communication
Submitted: 11 Jun 2021
Accepted: 27 Jul 2021
First published: 27 Jul 2021
This article is Open Access

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Chem. Commun., 2021,57, 8456-8459

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Pd-catalyzed C(sp³)–C(sp) bond formation in iodocyclobutenes

C. Lázaro-Milla, M. T. Quirós, D. J. Cárdenas and P. Almendros, Chem. Commun., 2021, 57, 8456 DOI: 10.1039/D1CC03087F

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