Facile synthesis of spherical covalent organic frameworks as stationary phases for short-column liquid chromatography

Abstract

Micron-sized spherical covalent organic frameworks (S_COFs) with tunable sizes, narrow size distribution, and significant mono-dispersity were simply synthesized at room temperature. Thanks to their high specific surface areas, high chemical and mechanical stability, the S_COFs were used for the first time as stationary phases for high-efficiency separation of various small molecules and protein digests via short-column liquid chromatography.