N-Hydroxyphthalimide-catalyzed chemoselective benzylic C(sp3)–H amination of unprotected arylalkanols using bis(2,2,2-trichloroethyl)azodicarboxylate has been developed. The use of 1,1,1,3,3,3-hexafluoropropan-2-ol as a solvent plays a critical role in chemoselectivity. The conversion of an aminated product to the corresponding free amino alcohol was also demonstrated.
M. Shibuya, T. Orihashi, Y. Li and Y. Yamamoto, Chem. Commun., 2021, 57, 8742 DOI: 10.1039/D1CC03466A
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