SbCl3 initiated conjunctive C–H bond functionalization and carbochlorination between glycine esters and methylenecyclopropanes (MCPs)

Abstract

In the presence of dioxygen, an antimony trichloride enabled conjunctive sp³ C–H bond functionalization and carbochlorination of glycines was realized, providing a series of chlorinated quinolines in high yields. The mechanistic study shows that the antimony(V) species might be involved in the oxidation of the sp³ C–H bond and is followed by carbochlorination through a radical intermediate.