A highly enantioselective vinylogous Mukaiyama aldol reaction to ketoesters catalysed by a hydrogen-bond-donor-based bifunctional organocatalyst is presented. The addition of silyloxy dienol ether gives rise to multifunctional chiral tertiary alcohols bearing a versatile α,β-unsaturated aldehyde with excellent enantiocontrol.
R. del Río-Rodríguez, V. Laina-Martín, J. A. Fernández-Salas and J. Alemán, Chem. Commun., 2021, 57, 11665 DOI: 10.1039/D1CC04263G
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