Cell imaging with multi-color DNA framework probes

Mo Xie; Linjie Guo; Shu Xing; Shuting Cao; Ziwei Zhao; Kaiyi Liang; Jiang Li; Shihua Luo; Yu Zhang; Lianhui Wang

doi:10.1039/D1CC04305F

Cell imaging with multi-color DNA framework probes†

Mo Xie,‡^a Linjie Guo,‡^bc Shu Xing,^d Shuting Cao,^c Ziwei Zhao,^ae Kaiyi Liang,^f Jiang Li,^bc Shihua Luo,*^g Yu Zhang

*^bc and Lianhui Wang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: iamlhwang@njupt.edu.cn

^b Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, The Interdisciplinary Research Center, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China
E-mail: zhangyu@sari.ac.cn

^c Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

^d Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China

^e Shanghai Frontier Innovation Research Institute Co., Ltd., Shanghai 201108, China

^f Radiology Department of Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Key Laboratory of Shanghai Municipal Health Commission for Smart Image, Shanghai 201800, China

^g Department of Traumatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
E-mail: jqab@163.com

Abstract

Utilizing the programmability of the fractal DNA frameworks, multi-color probes were constructed by arranging fluorescent molecules and nucleic acid aptamers on the structure. Multiplexed cell imaging and classification was realized through pattern recognition.

Chemical Communications

Cell imaging with multi-color DNA framework probes†

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Cell imaging with multi-color DNA framework probes

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