Issue 96, 2021

Layer-by-layer coating and chemical cross-linking of multilayer polysaccharides on silica for mixed-mode HPLC application

Abstract

A facile, controllable and environmentally friendly method for fabricating a novel polysaccharide–silica composite stationary phase (SiO2@(HA-CS)12) was developed in this report. Two natural polysaccharides (hyaluronan acid and chitosan) were controllably coated on the silica surface using a layer-by-layer assembly technique, and then the polysaccharide shell was chemically cross-linked to improve the stability. The column efficiency of the SiO2@(HA-CS)12 column reached 74 000 plates per m in HILIC mode and 20 100 plates per m in IEC mode, which indicates great potential for separating polar and charged samples.

Graphical abstract: Layer-by-layer coating and chemical cross-linking of multilayer polysaccharides on silica for mixed-mode HPLC application

Supplementary files

Article information

Article type
Communication
Submitted
13 Aug 2021
Accepted
10 Nov 2021
First published
11 Nov 2021

Chem. Commun., 2021,57, 12956-12959

Layer-by-layer coating and chemical cross-linking of multilayer polysaccharides on silica for mixed-mode HPLC application

Z. Chu, M. Zhu, W. Zhang, Y. Zhao, X. Gong, Y. Jiang, L. Wu, R. Zhai, X. Dai and X. Fang, Chem. Commun., 2021, 57, 12956 DOI: 10.1039/D1CC04467B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements