Issue 81, 2021

Self-assembly of artificial sweetener aspartame adversely affects phospholipid membranes: plausible reason for its deleterious effects

Abstract

The prolonged intake of the artificial sweetener aspartame is known to have deleterious effects. Our biophysical experimentations indicate that aspartame forms self-assembled cytotoxic fibrillar etiologies that affect the intrinsic integrity of the phospholipid membrane bilayer through electrostatic interaction and hydrophobic insertion, thereby making the membrane less rigid and more heterogeneous.

Graphical abstract: Self-assembly of artificial sweetener aspartame adversely affects phospholipid membranes: plausible reason for its deleterious effects

Supplementary files

Article information

Article type
Communication
Submitted
14 Aug 2021
Accepted
08 Sep 2021
First published
08 Sep 2021

Chem. Commun., 2021,57, 10532-10535

Self-assembly of artificial sweetener aspartame adversely affects phospholipid membranes: plausible reason for its deleterious effects

S. Nandi, S. Layek, P. K. Nandi, N. Bera, R. Hazra and N. Sarkar, Chem. Commun., 2021, 57, 10532 DOI: 10.1039/D1CC04482F

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