Reductive Ni-catalysis for stereoselective carboarylation of terminal aryl alkynes

Abstract

Stereoselective dicarbofunctionalization of terminal aryl alkynes has been achieved through reductive Ni-catalysis. The exclusive regioselective and anti-addition selective alkylarylation of terminal alkynes is accomplished using alkyl iodide and aryl iodide as electrophilic coupling partners in the presence of NiBr₂ as the catalyst and Mn as an inexpensive reductant.