Issue 88, 2021
From the journal:

Chemical Communications

Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[c]quinolin-3-ones and benzo[b]azocin-2-ones†

Qiao Li,‡ab   Yun Cai,‡a   Yuanyuan Hu,a   Hongwei Jin,a   Fener Chen, ORCID logo *bc   Yunkui Liu ORCID logo *a  and  Bingwei Zhou ORCID logo *a  

* Corresponding authors

a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China
E-mail: ykuiliu@zjut.edu.cn, zhoubw@zjut.edu.cn

b Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou, China

c Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, China
E-mail: rfchen@fudan.edu.cn

Abstract

We herein described a nickel-catalyzed cyclization of N-(o-ethynylaryl)acrylamides for the selective synthesis of dihydrocyclobuta[c]quinolin-3-ones and benzo[b]azocin-2-ones. The two varied products could be easily obtained by tuning the reaction temperature. This reaction features easy temperature-control, high efficiency, and gram-scale synthesis.

Graphical abstract: Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[c]quinolin-3-ones and benzo[b]azocin-2-ones

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Article information

DOI
https://doi.org/10.1039/D1CC04750G
Article type
Communication
Submitted
26 Aug 2021
Accepted
11 Oct 2021
First published
12 Oct 2021

Chem. Commun., 2021,57, 11657-11660

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Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[c]quinolin-3-ones and benzo[b]azocin-2-ones

Q. Li, Y. Cai, Y. Hu, H. Jin, F. Chen, Y. Liu and B. Zhou, Chem. Commun., 2021, 57, 11657 DOI: 10.1039/D1CC04750G

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