Issue 90, 2021
From the journal:

Chemical Communications

Tuning the organelle specificity and cytotoxicity of iridium(iii) photosensitisers for enhanced phototheranostic applications†

Jing-Hui Zhu, ORCID logo a   Guang-Xi Xu, ORCID logo a   Justin Shum, ORCID logo a   Lawrence Cho-Cheung Lee ORCID logo a  and  Kenneth Kam-Wing Lo ORCID logo *abc  

* Corresponding authors

a Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China
E-mail: bhkenlo@cityu.edu.hk

b State Key Laboratory of Terahertz and Millimetre Waves, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China

c Centre of Functional Photonics, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China

Abstract

Luminescent cyclometallated iridium(III) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.

Graphical abstract: Tuning the organelle specificity and cytotoxicity of iridium(iii) photosensitisers for enhanced phototheranostic applications

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Article information

DOI
https://doi.org/10.1039/D1CC04982H
Article type
Communication
Submitted
04 Sep 2021
Accepted
05 Oct 2021
First published
05 Oct 2021

Chem. Commun., 2021,57, 12008-12011

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Tuning the organelle specificity and cytotoxicity of iridium(III) photosensitisers for enhanced phototheranostic applications

J. Zhu, G. Xu, J. Shum, L. C. Lee and K. K. Lo, Chem. Commun., 2021, 57, 12008 DOI: 10.1039/D1CC04982H

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