Di-anionic self-associating supramolecular amphiphiles (SSAs) as antimicrobial agents against MRSA and Escherichia coli

Lisa J. White; Jessica E. Boles; Melanie Clifford; Bethany L. Patenall; Kira H. L. F. Hilton; Kendrick K. L. Ng; Rebecca J. Ellaby; Charlotte K. Hind; Daniel P. Mulvihill; Jennifer R. Hiscock

doi:10.1039/D1CC05455D

Di-anionic self-associating supramolecular amphiphiles (SSAs) as antimicrobial agents against MRSA and Escherichia coli†

Lisa J. White,^a Jessica E. Boles,^ab Melanie Clifford,^c Bethany L. Patenall,^c Kira H. L. F. Hilton,^a Kendrick K. L. Ng,^a Rebecca J. Ellaby,^a Charlotte K. Hind,*^c Daniel P. Mulvihill*^b and Jennifer R. Hiscock

*^a

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* Corresponding authors

^a School of Physical Sciences, University of Kent, Canterbury, Kent, UK
E-mail: J.R.Hiscock@Kent.ac.uk

^b School of Biosciences, University of Kent, Canterbury, Kent, UK
E-mail: D.P.Mulvihill@Kent.ac.uk

^c National Infection Service, Public Health England, Porton Down, Salisbury SP4 0JG, UK
E-mail: charlotte.hind@phe.gov.uk

Abstract

Herein, we report a series of di-anionic supramolecular self-associating amphiphiles (SSAs). We elucidate the antimicrobial properties of these SSAs against both methicillin resistant Staphylococcus aureus and Escherichia coli. In addition, we show this class of compound to form both intra- and intermolecular hydrogen bonded macrocyclic structures in the solid state.

Chemical Communications

Di-anionic self-associating supramolecular amphiphiles (SSAs) as antimicrobial agents against MRSA and Escherichia coli†

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Di-anionic self-associating supramolecular amphiphiles (SSAs) as antimicrobial agents against MRSA and Escherichia coli

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