Issue 5, 2021

One-pot crystallization of two 1,4-cyclohexanedicarboxylate-based tetranuclear Cu(ii) compounds and their DNA binding affinities

Abstract

Two new tetranuclear compounds [Cu4(cis-1,4-chdc)2(2,2′-bpy)4(H2O)4]·4(ClO4) (1) and [Cu4(cis-1,4-chdc)2(2,2′-bpy)42-OH)2]·2ClO4·2H2O (2) [1,4-H2chdc = 1,4-cyclohexanedicarboxylic acid, 2,2′-bpy = 2,2′-bipyridine] have been prepared by stirring copper(II) perchlorate hexahydrate [Cu(ClO4)2·6H2O] with 2,2′-bpy and the sodium-salt of 1,4-H2chdc. The compounds are formed in a one-pot crystallization and are visibly distinct in colour with dark blue and sky blue appearances, respectively, for 1 and 2. Both compounds have been characterized by elemental analysis as well as single crystal X-ray diffraction (SCXRD) techniques. Interestingly, both the compounds show significant DNA binding affinity with ctDNA and these experimental findings are further corroborated by a docking study. However, compound 1 with a higher cationic charge exhibits a better DNA binding affinity compared to 2.

Graphical abstract: One-pot crystallization of two 1,4-cyclohexanedicarboxylate-based tetranuclear Cu(ii) compounds and their DNA binding affinities

Supplementary files

Article information

Article type
Paper
Submitted
27 Nov 2020
Accepted
07 Dec 2020
First published
11 Dec 2020

CrystEngComm, 2021,23, 1091-1098

One-pot crystallization of two 1,4-cyclohexanedicarboxylate-based tetranuclear Cu(II) compounds and their DNA binding affinities

Akhtaruzzaman, M. Mohammad, S. Khan, B. Dutta, S. Maity, S. Naaz, S. M. Alam, P. Ghosh, Md. M. Islam and M. H. Mir, CrystEngComm, 2021, 23, 1091 DOI: 10.1039/D0CE01734E

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