Issue 1, 2021

Asymmetric desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metal catalysis

Abstract

This review is covering the recent development of catalytic asymmetric domino reactions for the desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metals and chiral ligands. This desymmetrization has emerged as an important strategy for the rapid construction of complex molecular skeletons, such as fused-polycycles or spirocyclic compounds in controlling multiple stereogenic centers.

Graphical abstract: Asymmetric desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metal catalysis

Article information

Article type
Review Article
Submitted
03 Jul 2020
First published
07 Dec 2020

Chem. Soc. Rev., 2021,50, 658-666

Asymmetric desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metal catalysis

T. Shu and J. Cossy, Chem. Soc. Rev., 2021, 50, 658 DOI: 10.1039/D0CS00666A

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