Issue 7, 2021
From the journal:

Green Chemistry

Gram-scale production of sugar nucleotides and their derivatives†

Shuang Li,‡a   Shuaishuai Wang, ORCID logo ‡b   Yaqian Wang,a   Jingyao Qu,c   Xian-wei Liu,a   Peng George Wangd  and  Junqiang Fang ORCID logo *a  

* Corresponding authors

a National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Glycochemistry and Glycobiology, Shandong University, Qingdao, Shandong 266237, People's Republic of China
E-mail: fangjunqiang@sdu.edu.cn

b Department of Chemistry, George State University, Atlanta, GA, USA

c State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, People's Republic of China

d School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, People's Republic of China

Abstract

Here, we report a practical sugar nucleotide production strategy that combined a high-concentrated multi-enzyme catalyzed reaction and a robust chromatography-free selective precipitation purification process. Twelve sugar nucleotides were synthesized on a gram scale with a purity up to 98%.

Graphical abstract: Gram-scale production of sugar nucleotides and their derivatives

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Article information

DOI
https://doi.org/10.1039/D1GC00711D
Article type
Communication
Submitted
24 Feb 2021
Accepted
12 Mar 2021
First published
12 Mar 2021

Green Chem., 2021,23, 2628-2633

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Gram-scale production of sugar nucleotides and their derivatives

S. Li, S. Wang, Y. Wang, J. Qu, X. Liu, P. G. Wang and J. Fang, Green Chem., 2021, 23, 2628 DOI: 10.1039/D1GC00711D

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