Issue 10, 2021

Replacing halogenated solvents by a butyl acetate solution of bisphenol S in the transformations of indoles

Abstract

A butyl acetate solution of bisphenol S (BPS) was proved to be able to replace hazardous halogenated solvents in the transformation of indoles. Measurement with Kamlet–Taft solvatochromic parameters disclosed that the polarity of the BPS-containing butyl acetate was enhanced greatly. The protocol not only conferred a convenient way to minimize the use of halogenated solvents in the synthesis of indole derivatives, but also enabled successful recycling of both the butyl acetate solvent and BPS additive, strengthening the greenness of the reaction systems.

Graphical abstract: Replacing halogenated solvents by a butyl acetate solution of bisphenol S in the transformations of indoles

Supplementary files

Article information

Article type
Communication
Submitted
02 Mar 2021
Accepted
12 Apr 2021
First published
16 Apr 2021

Green Chem., 2021,23, 3588-3594

Replacing halogenated solvents by a butyl acetate solution of bisphenol S in the transformations of indoles

F. Gao, F. Ferlin, R. Bai, M. Li, L. Vaccaro and Y. Gu, Green Chem., 2021, 23, 3588 DOI: 10.1039/D1GC00778E

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