Issue 16, 2021

Inertial focusing and zeta potential measurements of single-nanoparticles using octet-nanochannels

Abstract

Capture-to-translocation dynamics control is an important issue for single-particle and -molecule analyses by resistive pulse waveforms. Here, we report on regulated motions for accurate zeta-potential assessments of single nanoscale objects passing through an octet-nanochannel. We observed ionic spike signals consisting of eight consecutive sub-pulses signifying the ion blockage at the eight sensing zones in series upon electrophoretic translocation of individual nanoparticles. We find an exponential decrease to saturation of the channel-to-channel translocation duration as a nanobead moves forward, reflecting the more restricted radial motion degrees of freedom via inertial effects at the downstream side of the octet channel. This finding enabled a protocol for single-nanoparticle zeta potential estimation impervious to the uncertainty stemming from the stochastic nature of the translocation dynamics. The multi-channel approach presented in this study may be used as a useful tool for analyzing particles and molecules of variable sizes.

Graphical abstract: Inertial focusing and zeta potential measurements of single-nanoparticles using octet-nanochannels

Supplementary files

Article information

Article type
Communication
Submitted
25 Mar 2021
Accepted
21 Jun 2021
First published
01 Jul 2021

Lab Chip, 2021,21, 3076-3085

Inertial focusing and zeta potential measurements of single-nanoparticles using octet-nanochannels

S. Kishimoto, M. Tsutsui, K. Yokota and M. Taniguchi, Lab Chip, 2021, 21, 3076 DOI: 10.1039/D1LC00239B

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