Issue 10, 2021

Assessment of dihydropyrimidinone-based nanocomposites as multifunctional anti-cancer drug

Abstract

Dihydropyrimidinones, which are known as Biginelli compounds, have been found to be tumor inhibitors in the last decade. Herein, novel carbon quantum dot–dihydropyrimidinone (CQD–DHPM) nanocomposites were prepared via a simple conjugation process by varying the ratio of DHPM to CQDs. This conjugation endowed fluorescence properties to the medicinal DHPM compound and offered multifunctionality. CQD–DHPM nanocomposites were tested for their anti-cancer activity against the human non-small cell lung cancer A549 cell line. It was found that conjugating CQDs with DHPM improved its anti-cancer activity and reduced its cytotoxicity towards healthy cells. The fluorescence properties of composites also enabled them to serve as bioimaging fluorophores.

Graphical abstract: Assessment of dihydropyrimidinone-based nanocomposites as multifunctional anti-cancer drug

Supplementary files

Article information

Article type
Paper
Submitted
09 Jan 2021
Accepted
25 Mar 2021
First published
26 Mar 2021
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2021,2, 3385-3393

Assessment of dihydropyrimidinone-based nanocomposites as multifunctional anti-cancer drug

T. S., H. P. Mahendran, R. R. Bhattacharjee, S. Jeyaraj and K. Mohanta, Mater. Adv., 2021, 2, 3385 DOI: 10.1039/D1MA00017A

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