Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

Xingang Liu; Min Wu; Meng Wang; Yukun Duan; ChiUyen Phan; Guobin Qi; Guping Tang; Bin Liu

doi:10.1039/D0MH01582B

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Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy†

Xingang Liu,‡^a Min Wu,‡^a Meng Wang,^b Yukun Duan,^a ChiUyen Phan,^c Guobin Qi,^a Guping Tang

*^c and Bin Liu

*^ad

Author affiliations

* Corresponding authors

^a Department of Chemical and Biomolecular Engineering, National University of Singapore, Engineering Drive 4, Singapore
E-mail: cheliub@nus.edu.sg

^b Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou 310003, China

^c Department of Chemistry, Zhejiang University, Hangzhou 310028, China
E-mail: tangguping@zju.edu.cn

^d Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China

Abstract

A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth.

This article is part of the themed collections: Celebrating International Women’s Day: Women in Materials Science and 2021 Materials Horizons Advisory Board collection

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Article information

DOI: https://doi.org/10.1039/D0MH01582B
Article type: Communication
Submitted: 04 Oct 2020
Accepted: 15 Dec 2020
First published: 16 Dec 2020

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Mater. Horiz., 2021,8, 1454-1460

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Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

X. Liu, M. Wu, M. Wang, Y. Duan, C. Phan, G. Qi, G. Tang and B. Liu, Mater. Horiz., 2021, 8, 1454 DOI: 10.1039/D0MH01582B

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Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy†

Abstract

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Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

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