Label-free sensing of virus-like particles below the sub-diffraction limit by wide-field photon state parametric imaging of a gold nanodot array

Xiao Jin; Heng Zhang; Bin Ni; Weiping Liu; Lianping Hou; John H. Marsh; Shengwei Ye; Xiao Sun; Xiaofeng Li; Shanhu Li; Lei Dong; Jamie Jiangmin Hou; Ming Sun; Bin Xu; Jichuan Xiong; Xuefeng Liu

doi:10.1039/D1NA00603G

Label-free sensing of virus-like particles below the sub-diffraction limit by wide-field photon state parametric imaging of a gold nanodot array†

Xiao Jin,

‡^a Heng Zhang,‡^a Bin Ni,^a Weiping Liu,^a Lianping Hou,^b John H. Marsh,

^b Shengwei Ye,^b Xiao Sun,^b Xiaofeng Li,^c Shanhu Li,^d Lei Dong,^e Jamie Jiangmin Hou,

^f Ming Sun,^a Bin Xu,^a Jichuan Xiong

*^a and Xuefeng Liu

*^a

Author affiliations

* Corresponding authors

^a School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China
E-mail: liuxf_1956@sina.com, jichuan.xiong@njust.edu.cn

^b James Watt School of Engineering, University of Glasgow, Glasgow, UK

^c State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The first affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, P. R. China

^d Department of Cell Engineering, Beijing Institute of Biotechnology, Beijing, P. R. China

^e School of Life Science, Beijing Institute of Technology, Beijing 100081, P. R. China

^f The Royal College of Surgeons of Edinburgh, Nicolson Street, Edinburgh, Scotland, UK

Abstract

A parallel four-quadrant sensing method utilizing a specially designed gold nanodot array is created for sensing virus-like particles with a sub-diffraction limit size (∼100 nm) in a wide-field image. Direct label-free sensing of viruses using multiple four-quadrant sensing channels in parallel in a wide-field view enables the possibility of high-throughput onsite screening of viruses.

$Graphical abstract: Label-free sensing of virus-like particles below the sub-diffraction limit by wide-field photon state parametric imaging of a gold nanodot array$

Nanoscale Advances

Label-free sensing of virus-like particles below the sub-diffraction limit by wide-field photon state parametric imaging of a gold nanodot array†

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