Issue 34, 2021

Laser-induced switching of the biological activity of phosphonate molecules

Abstract

Butyrylcholinesterase inhibition and its enhancement as a result of laser irradiation are demonstrated for the first time for a series of phosphorylated arylaminomalonates. The effect of substituents in the phenyl group on butyrylcholinesterase inhibition and its laser-activated enhancement is revealed experimentally and confirmed by molecular dynamics and docking modelling.

Graphical abstract: Laser-induced switching of the biological activity of phosphonate molecules

Supplementary files

Article information

Article type
Communication
Submitted
20 May 2021
Accepted
09 Aug 2021
First published
09 Aug 2021

New J. Chem., 2021,45, 15195-15199

Laser-induced switching of the biological activity of phosphonate molecules

I. Kolesnikov, A. Khokhlova, D. Pankin, A. Pilip, A. Egorova, V. Zigel, M. Gureev, G. Leuchs and A. Manshina, New J. Chem., 2021, 45, 15195 DOI: 10.1039/D1NJ02487F

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