Issue 36, 2021

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde

Abstract

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and good tolerance of various substituents make it an alternative approach to previous protocols, and potential applications of these investigated compounds are expected with or without post-modifications.

Graphical abstract: Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde

Supplementary files

Article information

Article type
Communication
Submitted
26 Jul 2021
Accepted
16 Aug 2021
First published
17 Aug 2021

New J. Chem., 2021,45, 16430-16433

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde

X. Huo, X. Chen, L. Yu, C. Zhang, L. Zeng, H. Zhu, J. Shao, L. Fu and J. Zhang, New J. Chem., 2021, 45, 16430 DOI: 10.1039/D1NJ03596G

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