Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari†
James W.
Marshall, 
a
Iman A. Y.
Ghannam,
ac
Russell J.
Cox,
ad
Christine L.
Willis
a
and
Thomas J.
Simpson
*a
a
Iman A. Y.
Ghannam,
ac
Russell J.
Cox,
ad
Christine L.
Willis
a
and
Thomas J.
Simpson
*a
Abstract
Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.
- This article is part of the themed collection: Chemical Biology in OBC
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