Sc(OTf)3-catalyzed [3 + 2]-cycloaddition of nitrones with ynones†
Zhen-Ting
Du, 
b
Chang-Mei
Si
*a
and
b
Chang-Mei
Si
*a
and
Abstract
An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa–11aw, 11ba–11la and 12aa–12ae in moderate to good yields.
![Graphical abstract: Sc(OTf)3-catalyzed [3 + 2]-cycloaddition of nitrones with ynones](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D0OB02158J&imageInfo.ImageIdentifier.Year=2021)
- This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC
Please wait while we load your content...
