NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds

Abstract

In modern organic synthesis, the execution of reactions in the absence of expensive transition metals has received significant attention from the view-point of green chemistry and sustainable development. As a consequence, the combination of MI-TBHP as an oxidation system (M = Na, K, NH₄) has opened a new avenue with significant impact for the succinct synthesis of complex heterocycle molecules via the construction of various chemical bonds [C–X (X = C, N, S, O), N–X (X = N, P) and S–N]. This comprehensive review article delineates the progress of recent developments in this emerging area, with an in-depth discussion on the substrate scope, limitations and proper mechanistic underpinnings. We hope this review will highlight the great potential of this MI-TBHP as a powerful oxidation system and inspire researchers to conduct further endeavors in this domain.