Zn(OTf)2-catalyzed hydroamination of ynamides with aromatic amines†
Bang-Guo
Wei 
*b
*b
Abstract
The Zn(OTf)2-catalyzed hydroamination of ynamides 2a–2l with aromatic amines 1a–1r was developed. This protocol features broad substrate scope of aromatic amines, good functional group tolerance for ynamides, and excellent regioselectivities. As a result, a variety of substituted amidine compounds 3aa–3oa, 3ab–3al and 3pa–3rk were prepared in moderate to excellent yields and with high regioselectivities.
- This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC
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