Nickel-promoted oxidative domino Csp3–H/N–H bond double-isocyanide insertion reaction to construct pyrrolin-2-ones†
Li-Rong
Wen, 
a
Lin-Bao
Zhang
*a
and
a
Lin-Bao
Zhang
*a
and
Abstract
The first nickel-catalyzed oxidative domino Csp3–H/N–H double isocyanide insertion reaction of acetamides with isocyanides has been developed for the synthesis of pyrrolin-2-one derivatives. A wide range of acetamides bearing various functional groups are compatible with this reaction system by utilizing Ni(acac)2 as a catalyst. In this transformation, isocyanide could serve as a C1 connector and insert into the inactive Csp3–H bond, representing an effective way to construct heterocycles.
- This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC
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