Issue 18, 2021

Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis

Abstract

In the last two decades tremendous progress has been made in transition-metal (TM)-catalyzed C–H bond functionalization, paving the way to design complex molecules. Despite significant advances, enantioselective C–H activation is still in the age of infancy. For the enantioselective synthesis, several TM catalyst based approaches are well known, including kinetic resolution (KR) and its advanced versions [dynamic kinetic resolution (DKR) and parallel kinetic resolution (PKR)]. These strategies have recently been successfully applied synergetically with the TM catalyzed C–H activation to achieve enantioselective synthesis in a more economical and sustainable way. This review will summarize the recent advancements made towards merging KR with TM-catalysed C–H activation for enantioselective synthesis.

Graphical abstract: Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis

Article information

Article type
Review Article
Submitted
05 Feb 2021
Accepted
18 Mar 2021
First published
19 Mar 2021

Org. Biomol. Chem., 2021,19, 4014-4026

Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis

Sumit, D. Chandra and U. Sharma, Org. Biomol. Chem., 2021, 19, 4014 DOI: 10.1039/D1OB00232E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements