Issue 28, 2021

Iridium-catalyzed regioselective hydrosilylation of internal alkynes facilitated by directing and steric effects

Abstract

Here we reported the iridium-catalyzed hydrosilylation of internal alkynes under simple and mild conditions. The intrinsic functional groups of alkyne substrates were disclosed to be crucial in facilitating both the hydrosilylation process and related regioselectivity owing to their coordination capability towards the iridium catalyst. Utilization of the steric trimethylsilyl-protected trihydroxysilane proved to be another critical factor in ensuring the efficient proceeding of this process.

Graphical abstract: Iridium-catalyzed regioselective hydrosilylation of internal alkynes facilitated by directing and steric effects

Supplementary files

Article information

Article type
Communication
Submitted
10 May 2021
Accepted
24 Jun 2021
First published
24 Jun 2021

Org. Biomol. Chem., 2021,19, 6216-6220

Iridium-catalyzed regioselective hydrosilylation of internal alkynes facilitated by directing and steric effects

W. Gao, H. Ding, T. Yu, Z. Wang and S. Ding, Org. Biomol. Chem., 2021, 19, 6216 DOI: 10.1039/D1OB00910A

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