Issue 30, 2021
From the journal:

Organic & Biomolecular Chemistry

A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles†

Yusuke Kobayashi, ORCID logo *a   Sota Masakado,b   Takuya Murai,a   Shohei Hamada, ORCID logo a   Takumi Furuta ORCID logo a  and  Yoshiji Takemoto ORCID logo *b  

* Corresponding authors

a Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan
E-mail: ykobayashi@mb.kyoto-phu.ac.jp

b Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: takemoto@pharm.kyoto-u.ac.jp

Abstract

ortho-Nitro-substituted N-trifluoroacetyl imino-λ3-iodane is a bench-stable trifluoroacetyl nitrene precursor, in which intra- and intermolecular halogen bonding (XB) plays an important role. Potential synthetic applications of this novel precursor were explored.

Graphical abstract: A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles

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Article information

DOI
https://doi.org/10.1039/D1OB00947H
Article type
Communication
Submitted
14 May 2021
Accepted
07 Jul 2021
First published
07 Jul 2021

Org. Biomol. Chem., 2021,19, 6628-6632

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A bench-stable N-trifluoroacetyl nitrene equivalent for a simple synthesis of 2-trifluoromethyl oxazoles

Y. Kobayashi, S. Masakado, T. Murai, S. Hamada, T. Furuta and Y. Takemoto, Org. Biomol. Chem., 2021, 19, 6628 DOI: 10.1039/D1OB00947H

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