Issue 37, 2021
From the journal:

Organic & Biomolecular Chemistry

A triple-targeting delivery system carrying two anticancer agents†

Hui Li,a   Chang-Hee Leea  and  Injae Shin ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea
E-mail: injae@yonsei.ac.kr

Abstract

To improve tumor selectivity, a triple-targeting delivery system (Oct-FK(PBA-Az)-Dox) carrying two anticancer agents (apoptozole (Az) and doxorubicin (Dox)) was designed and synthesized. The results showed that both anticancer agents in Oct-FK(PBA-Az)-Dox are liberated in the presence of both H2O2 and cathepsin B, which are normally present at high levels in tumors.

Graphical abstract: A triple-targeting delivery system carrying two anticancer agents

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1OB01089A
Article type
Communication
Submitted
05 Jun 2021
Accepted
01 Jul 2021
First published
08 Jul 2021

Org. Biomol. Chem., 2021,19, 8009-8013

Permissions

Request permissions

A triple-targeting delivery system carrying two anticancer agents

H. Li, C. Lee and I. Shin, Org. Biomol. Chem., 2021, 19, 8009 DOI: 10.1039/D1OB01089A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements