One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF6 system

Veeranna Guguloth; Ramesh Balaboina; Narasimha Swamy Thirukovela; Ravinder Vadde

doi:10.1039/D1OB01132D

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One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF₆ system†

Veeranna Guguloth,^a Ramesh Balaboina,^a Narasimha Swamy Thirukovela*^b and Ravinder Vadde

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Kakatiya University, Warangal, T.S., India
E-mail: ravichemkuc@gmail.com

^b Department of Chemistry, Chaitanya (Deemed to be University), Warangal, T.S., India

Abstract

A one-pot three-component reaction of several 2-ketoaldehydes, secondary amines and terminal alkynes to access 3-aminofurans proceeded well in [bmim][PF₆] using a simple and cheap CuI catalyst. The resultant 3-aminofuran products were easily isolated using diethyl ether and the CuI/[bmim][PF₆] system was reused six times with a slight decrease in the activity.

This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC

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Article information

DOI: https://doi.org/10.1039/D1OB01132D
Article type: Paper
Submitted: 11 Jun 2021
Accepted: 04 Aug 2021
First published: 04 Aug 2021

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Org. Biomol. Chem., 2021,19, 7438-7445

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One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF₆ system

V. Guguloth, R. Balaboina, N. S. Thirukovela and R. Vadde, Org. Biomol. Chem., 2021, 19, 7438 DOI: 10.1039/D1OB01132D

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Organic & Biomolecular Chemistry