Y(OTf)3-catalyzed phosphorylation of 2H-chromene hemiacetals with P(O)–H compounds to 2-phosphorylated 2H-chromenes†
Abstract
A facile synthesis of 2-phosphorylated 2H-chromenes has been accomplished herein via a Y(OTf)3-catalyzed dehydrative coupling of 2H-chromene hemiacetals with P(O)–H compounds. This protocol features low catalyst loading, mild reaction conditions, broad substrate scope and easy elaboration of the products.
- This article is part of the themed collection: Synthetic methodology in OBC