Issue 38, 2021
From the journal:

Organic & Biomolecular Chemistry

Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN†

Qing-Wen Gui, ORCID logo *ab   Zhi-Yuan Xiong,a   Fan Teng, ORCID logo a   Tian-Cheng Cai,a   Qiang Li,*ac   Wenxia Hu,a   Xiaoli Wang,a   Jialing Yua  and  Xiaoying Liu*a  

* Corresponding authors

a College of Chemistry and Materials Science, Hunan Agricultural University, Changsha 410128, People's Republic of China
E-mail: gqw1216@hunau.edu.cn, gqw1216@163.com

b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China

c College of Agronomy, Hunan Agricultural University, Changsha 410128, People's Republic of China

Abstract

The electrochemical α-cyanation of tertiary and secondary amines has been developed by using a cheap cyanide reagent, azobisisobutyronitrile (AIBN). The CN radical, generated through n-Bu4NBr-meidated electrochemical oxidation, participates in a novel α-cyanation reaction under exogenous oxidant-free conditions.

Graphical abstract: Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN

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Article information

DOI
https://doi.org/10.1039/D1OB01416A
Article type
Communication
Submitted
21 Jul 2021
Accepted
01 Sep 2021
First published
04 Sep 2021

Org. Biomol. Chem., 2021,19, 8254-8258

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Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN

Q. Gui, Z. Xiong, F. Teng, T. Cai, Q. Li, W. Hu, X. Wang, J. Yu and X. Liu, Org. Biomol. Chem., 2021, 19, 8254 DOI: 10.1039/D1OB01416A

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