Vinyl sulfone synthesis via copper-catalyzed three-component decarboxylative addition

Abstract

The synthesis of vinyl sulfone derivatives via the reaction of arylpropiolic acids, K₂S₂O₅, and aryl boronic acids is reported. The CuBr₂/1,10-phenanthroline catalytic system in the presence of acetic acid provides the desired vinyl sulfones in moderate to good yield. Furthermore, the methodology features excellent functional group tolerance.