Application of combined cyanide sources in cyanation reactions

Abstract

The cyanation reaction is a key transformation due to the wide-ranging applications of nitrile compounds in organic chemistry. Traditionally, the cyanation reaction employs metal cyanides as cyanide sources, which are toxic and environmentally unfriendly. Very recently, many excellent examples of using combined cyanide sources as cyanating agents have been reported. This review summarizes the applications of combined cyano-group sources in a variety of cyanation reactions.