Issue 40, 2021

Photoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes

Abstract

A mild and facile approach to construct various perfluoroketones via photo-catalyzed difluoroalkylation of difluoroenoxysilanes is developed. The reaction includes a strategy of combination of two fluorine-containing functional groups, which confers the reaction with characteristics like high efficiency, mild conditions, and broad scope. A variety of fluoroalkyl halides including perfluoroalkyl iodides, bromo difluoro esters and amides can be employed as radical precursors. Control experiments indicate that a single-electron transfer pathway may be involved in the reaction.

Graphical abstract: Photoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes

Supplementary files

Article information

Article type
Communication
Submitted
04 Aug 2021
Accepted
17 Sep 2021
First published
18 Sep 2021

Org. Biomol. Chem., 2021,19, 8696-8700

Photoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes

J. Zou, Y. Wang, W. Sun, W. Lin and X. Liu, Org. Biomol. Chem., 2021, 19, 8696 DOI: 10.1039/D1OB01530C

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