Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine†
Matteo
Faltracco 
a
and
Eelco
Ruijter
*a
a
and
Eelco
Ruijter
*a
Abstract
Judicious substrate design allows interruption of the classical Bischler–Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine.
- This article is part of the themed collection: Total synthesis in OBC
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