Issue 47, 2021

Synthesis of 3-halogenated 2,3′-biindoles by a copper-mediated 2,3-difunctionalization of indoles

Abstract

A copper-mediated 2,3-difunctionalization of indoles to afford 3-halogenated 2,3′-biindoles is described herein. The protocol uses readily available feedstocks and a naturally abundant copper catalyst system, which allows the regioselective formation of C–C and C–X (X = Cl & Br) bonds in one single operation. Here the copper metal salt serves not only as a catalyst but also as a reactant to provide the source of halogen. This operationally simple procedure avoids the utilization of environmentally unfriendly reagents and displays good functional group compatibility. Noteworthily, the introduction of halogen into molecules would offer great potential for further chemical transformations.

Graphical abstract: Synthesis of 3-halogenated 2,3′-biindoles by a copper-mediated 2,3-difunctionalization of indoles

Supplementary files

Article information

Article type
Paper
Submitted
15 Oct 2021
Accepted
19 Nov 2021
First published
19 Nov 2021

Org. Biomol. Chem., 2021,19, 10403-10407

Synthesis of 3-halogenated 2,3′-biindoles by a copper-mediated 2,3-difunctionalization of indoles

X. Zhang, Y. Zhang, X. Gu, Z. Zhang, W. Wei and T. Liang, Org. Biomol. Chem., 2021, 19, 10403 DOI: 10.1039/D1OB02024B

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