Issue 47, 2021

Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions

Abstract

We synthesized cinnamoyl amide type chiral P,olefin ligand (S)-4. We successfully obtained separable diastereomers of 4d and demonstrated Pd-catalyzed asymmetric allylic substitution reactions of indoles using (S,aS)-4d as a chiral ligand with high enantioselectivities (up to 98% ee).

Graphical abstract: Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions

Supplementary files

Article information

Article type
Paper
Submitted
25 Oct 2021
Accepted
12 Nov 2021
First published
15 Nov 2021

Org. Biomol. Chem., 2021,19, 10385-10389

Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions

T. Mino, Y. Fujisawa, S. Yoshida, M. Hirama, T. Akiyama, R. Saito, Y. Yoshida, Y. Kasashima and M. Sakamoto, Org. Biomol. Chem., 2021, 19, 10385 DOI: 10.1039/D1OB02086B

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