Cinnamoyl amide type chiral P,olefin ligands for Pd-catalyzed reactions†
Abstract
We synthesized cinnamoyl amide type chiral P,olefin ligand (S)-4. We successfully obtained separable diastereomers of 4d and demonstrated Pd-catalyzed asymmetric allylic substitution reactions of indoles using (S,aS)-4d as a chiral ligand with high enantioselectivities (up to 98% ee).
- This article is part of the themed collection: Synthetic methodology in OBC