Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides

Kesar Jagdev; Damiano Tanini; Jack W. Lownes; Carlotta Figliola; Louise Male; Antonella Capperucci; Richard S. Grainger

doi:10.1039/D1OB02153B

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Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides†

Kesar Jagdev,

^a Damiano Tanini,

^b Jack W. Lownes,

^a Carlotta Figliola,

^a Louise Male,

^a Antonella Capperucci

^b and Richard S. Grainger

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
E-mail: r.s.grainger@bham.ac.uk

^b University of Florence, Department of Chemistry “Ugo Shiff”, Via della Lastruccia 13, 1-50019 Sesto Fiorentino, Italy

Abstract

Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

This article is part of the themed collection: Catalysis & biocatalysis in OBC

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DOI: https://doi.org/10.1039/D1OB02153B
Article type: Communication
Submitted: 02 Nov 2021
Accepted: 19 Nov 2021
First published: 30 Nov 2021
This article is Open Access

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Org. Biomol. Chem., 2021,19, 10565-10569

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Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides

K. Jagdev, D. Tanini, J. W. Lownes, C. Figliola, L. Male, A. Capperucci and R. S. Grainger, Org. Biomol. Chem., 2021, 19, 10565 DOI: 10.1039/D1OB02153B

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Organic & Biomolecular Chemistry

Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides†

Abstract

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Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides

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