Issue 20, 2021
From the journal:

Polymer Chemistry

An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels†

Sumanta Samanta, ORCID logo a   Vignesh K. Rangasami,a   N. Arul Murugan,b   Vijay Singh Parihar, ORCID logo a   Oommen P. Varghese ORCID logo c  and  Oommen P. Oommen ORCID logo *a  

* Corresponding authors

a Bioengineering and Nanomedicine Lab, Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland
E-mail: oommen.oommen@tuni.fi

b Department of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, S-106 91 Stockholm, Sweden

c Translational Chemical Biology Laboratory, Polymer Chemistry Division, Department of Chemistry, Ångström Laboratory, Uppsala University, 75121 Uppsala, Sweden

Abstract

We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA–GA scaffolds are superior to HA–DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response.

Graphical abstract: An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

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Article information

DOI
https://doi.org/10.1039/D1PY00013F
Article type
Communication
Submitted
04 Jan 2021
Accepted
30 Mar 2021
First published
31 Mar 2021
This article is Open Access
Creative Commons BY-NC license

Polym. Chem., 2021,12, 2987-2991

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An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

S. Samanta, V. K. Rangasami, N. A. Murugan, V. S. Parihar, O. P. Varghese and O. P. Oommen, Polym. Chem., 2021, 12, 2987 DOI: 10.1039/D1PY00013F

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