Issue 42, 2021

Rapid preparation and characterization of a bridged bis(β-cyclodextrin) functionalized urea–formaldehyde monolithic column by a “one-pot” approach

Abstract

In this study, a new bridged bis(β-cyclodextrin) (CD) functionalized urea–formaldehyde monolithic column was prepared by “one-pot” method within 30 minutes. The structures of bridged-CD and the obtained monolithic column were characterized by scanning electron microscopy, nuclear magnetic resonance spectroscopy, infrared spectroscopy and energy dispersive spectroscopy. The chromatographic performance of native-CD-monolith, N,N′-methylenebisacrylamide (MBA)-bridged-CD-monolith and N,N′-(1,2-dihydroxyethylene) bisacrylamide (DAA)-bridged-CD-monolith was systematically evaluated by separating five analytes. As a result, all tested analytes were separated on an MBA-bridged-CD-monolith and DAA-bridged-CD-monolith with high resolutions (1.21–6.80), which showed that the bridged-CD-monolith exhibited a better chromatographic performance with enantioselectivity due to providing mixed-modes such as hydrophilicity, hydrogen bonding, ionic dipole and synergy compared with those of the native-CD-monolith. In addition, the enantioselectivity of the bridged-CD-monolith was related to the polarity of a functional linker. As a new chiral separation material, the bridged-CD functionalized urea–formaldehyde monolithic column may be widely applied in the analysis of chiral compounds due to its rapid preparation and higher enantioseparation performance.

Graphical abstract: Rapid preparation and characterization of a bridged bis(β-cyclodextrin) functionalized urea–formaldehyde monolithic column by a “one-pot” approach

Supplementary files

Article information

Article type
Paper
Submitted
07 Jul 2021
Accepted
01 Oct 2021
First published
13 Oct 2021

Polym. Chem., 2021,12, 6123-6133

Rapid preparation and characterization of a bridged bis(β-cyclodextrin) functionalized urea–formaldehyde monolithic column by a “one-pot” approach

Y. Liu, Z. Su, S. Jiang, H. Sun, H. Lyu and Z. Xie, Polym. Chem., 2021, 12, 6123 DOI: 10.1039/D1PY00906K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements