Chiral lithium amide mediated desymmetrization of 3-substituted cyclobutanone

Abstract

We report here a practical strategy to access enantioenriched cyclobutenes via chiral lithium amide mediated deprotonation of 3-substituted cyclobutanones. Furthermore, this strategy has been applied to access protoilludane analogues via a sequential Negishi coupling of enol phosphates and Diels–Alder reaction.